Digital resilience, as the ability of enterprises using digital technology to respond to major shocks, has received extensive attention from society. Through a review of domestic and foreign literature, it is found that the digital resilience of enterprises mainly consists of the ability to absorb shocks, the ability to adapt to shocks, and the ability to recover to a steady state. The multi-case study method was used to identify the typical practices adopted by chemical enterprises in the process of building digital resilience. On this basis, these scattered typical practices were further summarized and integrated to construct a universal model of the digital resilience building path for chemical enterprises. Through dynamic management and control based on digital innovation, organizational collaboration based on digital platforms, resource aggregation based on industrial Internet platforms, and agile response based on business model innovation, it helps enterprises effectively defuse major shocks and promotes their transition to a new steady state.