By constructing a comprehensive evaluation system for the digital transformation of manufacturing and the development of the digital economy, the coupling and coordination status of these two systems across 30 provinces in China from 2011 to 2019 were analyzed. Their dynamic changes and regional disparities from multiple dimensions were further examined. The research reveals that during this period, both the level of digitalization in manufacturing and the development of the digital economy show an upward trend across all provinces. However, there remains a significant gap between the achieved level of system coupling and the benchmark for high coupling. Despite this, the overall coupling and coordination degree has been on an upward trend, indicating a positive interaction and progress between the two domains. Regional analysis demonstrates that the coupling degree among provinces first increases and then decreases from east to central and western regions. Conversely, the coupling and coordination degree decreases progressively from the eastern to the western region.