Safety evaluation is an important prerequisite and guarantee for the transportation of dangerous goods. Taking a dangerous goods transportation project in a town in southwest China as an example, the project area was divided into 8 evaluation units, and the safety check list method and fault tree method were used to evaluate the safety, and the main disaster control factors and safety work points were discussed. The results show that the safety checklist method is suitable for the inspection events specified in the specification provisions, and the fault tree method can effectively analyze the cause of the event and the weight of the elements through the minimum cut set and the importance calculation. The safety and security of transportation and loading and unloading operations should pay attention to the standardized operation of personnel, labor protection and safe location of the work area.