In the new era, the economy calls for high-quality development, and innovative productive forces are the cornerstone of achieving this goal. By employing methods such as literature review, field research and expert interviews, the practical path and application of blockchain technology in the transformation and upgrading of the integration of sports and medical industries in the Guangdong-Hong Kong-Macao Greater Bay Area, as well as regional coordinated development were deeply explored. The research suggests that the Greater Bay Area has significant advantages in policy, economy, society and technology, providing new opportunities for the vigorous development of the integration of sports and medical industries. Faced with the challenges of industrial transformation and upgrading, the construction of a blockchain-based alliance chain for the integration of sports and medical industries in the Greater Bay Area is proposed, integrating technology research and development, platform support, industry application, and service support to build a comprehensive industrial chain. It is aimed to promote the regional coordinated development of the real economy, drive innovation in social governance and the construction of a healthy city, and contribute key strength to achieving the Chinese modernization goals of a strong sports nation, a healthy China and a digital China.