From the aspects of innovation subject, innovation carrier, innovation elements and innovation environment, combs the current situation of innovation resources gathering in Tsukuba Science City was combed, and the process and characteristics of innovation resources gathering in Tsukuba Science City was analyzed from the micro perspective through detailed historical data collection and sorting. Based on the different development stages of Tsukuba Science City, the state led compulsory agglomeration mode of innovation resources, the spontaneous agglomeration mode of innovation resources driven by industry university research cooperation, and the agglomeration mode driven by collaborative innovation platform and innovation chain construction were provided. It is pointed out that Tsukuba Science City is evolving in two directions, such as the construction of innovation ecosystem and the development of high-tech and sophisticated industries. Finally, some experiences are put forward for Xiong'an New Area to learn from, such as attaching importance to the construction of superior universities and colleges, building a cross regional and cross subject platform system, and increasing the openness of application scenarios.