The emergence of innovation research and development institutes is the product of China's continuous improvement of innovation system construction under the background of implementing innovation-driven development strategy, which has played a huge role in promoting regional innovation cooperation and the transformation of scientific and technological achievements. Based on a total of 1 461 patents of 23 innovative R&D institutes in Tianjin, social network analysis was used to study the innovation cooperation of innovative R&D institutes and the transformation of scientific and technological achievements,. The results show that Tianjin has most independent R&D institutions, and the innovation ability gap between institutions is large.The innovation cooperation between institutions shows the characteristics of collectivization, and regional innovation cooperation needs to be improved. The conversion rate of scientific and technological achievements of institutions is much higher than that of general university research institutes. On this basis, targeted suggestions are put forward in order to provide reference for the government to formulate relevant policies.