In order to achieve innovation-driven development, county is the bias and vitality, but which is difficulty. Based on the monitoring and evaluation data of science and technology innovation of counties in Hebei Province from 2020 to 2021, the spatial econometrics method was used to study the spatial distribution characteristics, spatial aggregation and spatial spillover effect of science and technology innovation. The results show that the northwest region of Hebei is the lagging cluster area of scientific and technological innovation, while the central and eastern region adjacent to Beijing and Tianjin is the developed cluster area, which presenting the spatial pattern of "collapse in the northwest and rise in the central and eastern regions". From the perspective of spillover effect, county science and technology innovation - economic development, county science and technology innovation input - county science and technology innovation output have spatial spillover effect.