Open innovation is an important support for promoting new models, and has become a hot topic in innovation theory exploration and industrial practice. However, how to focus on the driving forces of open innovation and improve innovation effectiveness still needs to be studied urgently. Taking the “Internet +medical” innovation practice as the case scenario of open innovation, the external and internal drivers of open innovation were explored, an open innovation driver model was built, and open coding, spindle coding and selective coding were used to complete case data coding, and the drivers of “Internet +medical” open innovation, including mechanism innovation, data support, communication technology, institutional guarantee and data guarantee were incorporated, thus confirming the open innovation driver model constructed.