Proof of concept is an important link in the long chain of transformation of scientific and technological achievements. At present, the proof-of-concept center is being supported by more and more regions in China to open up the "first mile" of the transformation of scientific and technological achievements into industrialization. However, as a new innovation carrier, the construction of the PoC Center is facing many problems and challenges. On the basis of investigating multiple proof-of-concept center across the country, the exploration practices of different regions were sorted, and the current development characteristics, beneficial experiences and existing problems were summarized. It aims to provide reference and guidance for the country and regions to support and promote the proof-of-concept center better, in order to accelerate the transformation of scientific and technological achievements, and cultivate and develop new quality productivity.