Taking major science and technology project organization mode as the main line, comprehensive summary on the situation of major science and technology projects in Dongguan was conducted to analyze the problems and the insufficiency.In order to promote the development of science and technology innovation can assign high quality, learning from advanced city experience, some suggestions are put forward, including focusing on the municipal special scheduling mechanism, strengthening key areas of research and development projects for the basic point, the foothold, innovation organization and management mode for the breakthrough point, optimizing the service guarantee system for support dimension, gradually exploring to establish the characteristic of Dongguan science and technology project organization mode.