In order to gauge the extent of industrial agglomeration and environmental pollution, we utilize location entropy and comprehensive environmental pollution . Furthermore, we delve into the spatial distribution patterns of these two phenomena by examining their spatial correlations. To achieve this, we integrate the spatial error model, spatial lag model, and spatial Durbin model, ultimately selecting the Durbin model that incorporates spatial spillover effects. Leveraging this model, we conduct an empirical analysis of how industrial agglomeration impacts environmental pollution, particularly its spatial spillover effects. Additionally, we scrutinize the inherent relationship between industrial agglomeration and environmental pollution, along with its manifestations in the Guangdong Province. Specifically, through the spatial spillover effect of industrial agglomeration on environmental pollution, we provide a nuanced understanding of how these two phenomena are interconnected and manifest in Guangdong Province.