In order to provide guidance for the design of asphalt mixture in hot and humid areas, based on the Maozhan high-speed project, the climatic conditions of the project were analyzed, the functional requirements of asphalt pavement were sorted out, and the mixture design scheme for high hot and humid areas was recommended. The results show that after optimized design, the dynamic stability of skeleton-type AC-20 and SMA-13 asphalt mixture can be increased by more than 40% at 70℃.In order to improve the water stability of asphalt pavement, the appropriate target voidage and construction ratio scheme are recommended. The indoor accelerated polishing test shows that the anti-skid durability of SMA-13 is better than that of AC-16.The dynamic stability of the mixture using 50# hard asphalt is 150% higher than that of 70# asphalt, which has better adaptability and economy.