By studying the number and spatial distribution of industry-university-research patents in the "9+2" urban agglomeration of Guangdong-Hong Kong-Macao Greater Bay Area, the structural characteristics of industry-university-collaborative innovation network were analyzed. The findings are as follows. The industry-university collaborative innovation network in Guangdong-Hong Kong-Macao Greater Bay Area presents a loose network structure. There are great differences in industry-university cooperation relationship and cooperation degree among urban agglomerations, showing the characteristics of unbalanced spatial distribution. Universities occupy a leading position in the collaborative innovation network of the Guangdong-Hong Kong-Macao Greater Bay Area. It aims to promote the rapid development of the regional innovation system in the Guangdong-Hong Kong-Macao Greater Bay Area by promoting knowledge spillover from universities, integrating into the global innovation network, and promoting institutional and cultural synergy.