With the rapid development of China's nuclear power industry, the production capacity of nuclear fuel elements continues to improve, and the output of depleted uranium is also increasing , and most of the depleted uranium is temporarily stored in the production site. The main application of depleted uranium materials in civilian fields was introduced. summarizing the safety management of depleted uranium materials abroad, the treatment and destination of depleted uranium materials in discarded civilian equipment were sorted, the attitudes and safety supervision of depleted uranium materials in various countries were compared. Suggestions are put forward for the safety management of depleted uranium materials in China.