In order to explore the variation rule and influencing factors of the transverse distribution coefficient of hollow slab bridge, the finite element model of hollow slab bridge was established by using the finite element analysis software Midas Civil 2020, and the influence of wide span ratio and oblique angle on the transverse distribution coefficient of fabricated hollow slab bridge was studied. The results show that the transverse distribution coefficient of hollow slab bridge decreases with the increase of width-span ratio under vehicle load, and the transverse distribution coefficient of partial slab under vehicle load changes more gently than that of non-partial slab under vehicle load. With the increase of the oblique angle, the transverse distribution coefficient of the biased load side plate increases, and the transverse distribution coefficient of the non-biased load side plate decreases. When the inclination angle of hollow slab bridge is less than 20°, the increment of the lateral distribution coefficient of each plate on the off-load side is less than 5%, which can be approximately ignored in practical engineering. When the deviation angle is more than 30°, the impact on load distribution is great, which cannot be ignored in analysis.