As a new and efficient heat exchanger, the wrapped tube heat exchanger has the characteristics of high heat transfer coefficient, compact structure, and can be used for heat exchange of multiple fluids simultaneously. On the basis of an actual engineering heat exchange project involving CO2 and thermal oil, the effects of the spiral inclination angle θ, outer diameter of the wound tube D, radial clearance Pd, axial clearance Pl, core tube diameter DZ, and number of layers CS of the wound tube on the heat transfer performance, shell side pressure drop ΔPS, and tube side pressure drop ΔPT of the heat exchanger were studied. The results indicate that as θ, D, Pd, DZ and CS increase, as well as Pl decreases, the heat transfer performance of the heat exchanger gradually decreases. Among these structural parameters, the one with the greatest impact on heat transfer performance is θ, the smallest one is Pl. While changing the structural parameters to increase the heat transfer performance of the heat exchanger, it often leads to an increase in ΔPS and ΔPT.Therefore, when designing and calculating heat exchangers in practical engineering projects, it is necessary to comprehensively consider heat transfer performance and pressure drop, and ultimately design a wound tube heat exchanger with greater heat transfer performance within the allowable range for ΔPS and ΔPT.