Based on the entropy method, coupling model and coupling coordination model, relevant data from 2016 to 2021 was selected to analyze the comprehensive development level and coupling coordination degree of digital industrialization and industrial digitalization in Liaoning Province, and the obstacle degree model was selected to study the obstacle factors restricting the coupling and coordination of digital industrialization and industrial digitalization. The results show that the comprehensive development level and coupling coordination degree of digital industrialization and industrial digitalization in Liaoning Province show an upward trend on the whole, but the overall development level and coordination degree are still at a low level, and the investment and application level are the main obstacle factors. In the future, it is necessary to accelerate the improvement of digital infrastructure construction and improve innovation capabilities to promote the coupling and coordinated development of digital industrialization and industrial digitalization in Liaoning Province.