With the rapid development of digital economy, the strangulation mergers and acquisitions initiated by large digital platforms against startups to eliminate potential competition have brought new challenges to the regulation of traditional operator concentration. Currently, Anti monopoly Law of the People's Republic of China shows lagging effect on such mergers and acquisitions in terms of identification, assessment and ex post relief. In order to prevent disorderly expansion of capital and maintain the competitiveness of the market, the declaration standard should be improved by introducing the transaction amount and the obligation to notify specific platforms firstly.Then, the “reversal of the burden of proof” and the establishment of a special digital law enforcement department should be adopted to optimize the review of mergers and acquisitions. Finally, behavioral remedies are adopted for M&A behaviors identified as having the attribute of “strangulation”, and structural remedies are also adopted to build a long-term regulation of strangulated M&A.