Whole domain interest E-commerce is a major innovation in E-commerce. Based on the development status of Douyin E-commerce in all areas of interest E-commerce from 2021 to 2023，business methods is studied. The research found that from 2021 to 2023, Douyin E-commerce has a low net promoter value in sales recommendations; the coordination between E-commerce and marketing is poor in the sales process. The problem of operating efficiency that needs to be improved in terms of sales results. Based on this, suggestions are put forward: develop sustainable groups of people in terms of sales recommendations,provide good products at good prices during the sales process, and carry out full-field construction with content as the center in terms of sales results. Through the comprehensively analysis of the advantages and disadvantages of Douyin's new all-area interest E-commerce model, it is helpful to further improves the operating methods of the all-area interest E-commerce system, thereby achieving the sustainable development of Douyin E-commerce and providing guidance for the development of other e-commerce companies. sample.