Based on the perspective of coordinated development, an evaluation system for rural revitalization system and regional logistics system was constructed. The entropy weight method and coupling coordination model were used to explore the comprehensive level and spatiotemporal coupling relationship between rural revitalization system and regional logistics system in 11 provinces and cities in the Yangtze River Economic Belt from 2005 to 2020. The obstacle model was used to diagnose the main obstacle factors of each system. The results indicate that the overall coupling and coordination degree between the rural revitalization system and regional logistics system in various provinces and cities of the Yangtze River Economic Belt is on the rise, and the overall comprehensive index of both is not high, showing a logistics lagging development. The level of coupling and coordination between the two shows a spatial distribution pattern characterized by eastern>central>western, and "high coastal and low inland". According to the obstacle degree model, the scale of logistics development has the greatest impact on regional logistics development, and rural revitalization is mainly influenced by ecological livability and rural civilization.