By constructing a multidimensional index system and using the entropy weight method, the Digital Economy and High-quality Development Index were calculated. The coupling coordination model was adopted to analyze the interaction and coordination between the two. The research finds that from 2013 to 2022, the level of digital economy and high-quality development in the central region showed a stable upward trend, and the coupling coordination degree increased year by year. In addition, the variation coefficient is used to analyze the differences in these two aspects and their coupling coordination degree among the six provinces in the central region. Recommendations for promoting the digital economy and high-quality development in the central region include deepening the integration of the digital economy, enhancing talent cultivation and attraction, and promoting regional synergy.