An evaluation index system for the transformation of scientific and technological achievements in Jiangsu universities and an evaluation index system for the development level of high-tech industries was constructed. Based on relevant data from Jiangsu from 2018 to 2021, the coupling comprehensive value of the transformation system of scientific and technological achievements in Jiangsu universities and the development level system of high-tech industries was calculated using entropy weight method and coupling evaluation model, coupling correlation and coupling scheduling. It is found that there is a high degree of coupling between the transformation of scientific and technological achievements in Jiangsu universities and the development level of high-tech industries, but there is a significant difference in the degree of coupling coordination. The matching degree between the output of scientific and technological achievements in Jiangsu universities and the demand for high-tech industries is gradually increasing.