Self-reliance on high-level science and technology is the key to Chinese path to modernization. At present, under the Cold War mentality, the United States regards the field of science and technology as a geopolitical game stage and builds a key technology blockade network. In order to break through the blockade and suppress, and win the battle for key technologies, it is urgent to explore and summarize innovative development paths at different levels such as industry and technology. Three innovation models from macro, meso and micro perspectives were proposed, focusing on different innovation entities and demand scenarios, forming a pattern of key core technology dislocation and collaborative research. Specifically, at the macro level, it is a national major engineering driven development model under the new system for mobilizing resources nationwide, aiming for disruptive cutting-edge technological breakthroughs and mastering the initiative of innovative development. At the meso level, it adoptes a multi-level "Chain Length System" development model to achieve strong and complementary chains, and enhance the modernization level of the industrial chain. At the micro level, it adoptes a normalized " the Open Competition Mechanism to Select the Best Candidates" development model, using single point technological breakthroughs to achieve rapid response, stimulate endogenous potential and innovative vitality. The three models have extensive practical applications in the commercial aerospace field. Through innovative models and practical analysis in different scenarios, suggestions for further optimization of different models are proposed from the perspectives of focusing on technological development needs, creating an "Internal Circulation" of the industrial ecosystem, and casting more "the Pillars of a Great Power" to enhance key core technological capabilities.