Aviation safety is the lifeline of the development of civil aviation. Flight safety risk research is an important part of flight safety analysis. Research of flight safety risk influencing factors is an important basis for flight safety risk research. In order to study the influencing factors of civil aviation flight safety risk, on the basis of constructing the flight safety risk evaluation index system, the integrated DEMATEL-ISM algorithm was used to construct the influencing factor model of flight safety risk, and the in-depth analysis of the attributes, importance and action mechanism of the factors to establish a systematic multi-level hierarchical structure model. Finally, it is realized through numerical simulation, and the results are analyzed and researched in depth to discuss its practical application value and prove the feasibility and effectiveness of this method. This method can provide decision-making assistance and theoretical guidance for flight safety risk management, which helps to improve Flight safety management level.