The "transfer" of technological achievements is an important measure to maximize innovation-driven effectiveness and alleviate technology transfer difficulties. One of the important reasons for the failure of technology transfer is the lack of effective grasp and management of the inherent levels of technology needs. Based on the theory of hierarchical management, starting from the micro-level perspective of technical needs, a hierarchical targeting mechanism was built for technology transfer with the refined hierarchical system of technical needs as the core and with accurate identification, hierarchical targeting, and accurate feedback as key points. The establishment of the South China Technology Transfer Center is an important measure for the hierarchical targeting mechanism of technology transfer. Relying on the effective support of intellectual property system protection and big data drive, the hierarchical targeting mechanism of technology transfer can effectively promote the precise docking between technology supply and demand entities, guide the combination and allocation of technological innovation elements at different levels, and thus more effectively Realize the transfer and application of technological achievements.