Aiming to explore the scientific and technological innovation and industrial synergy development of the labor literacy evaluation system in vocational education, Python was used to conduct word frequency statistics and text analysis on the comprehensive quality evaluation texts of students from 20 higher vocational colleges. The analysis was conducted in two rounds. In the first round the high-frequency words first was analyzed, and the current research pattern of the comprehensive quality of students in higher vocational colleges was clarified. The second round focused on the perspective of scientific and technological innovation and industrial synergy development, and the focus of labor literacy evaluation of different regional colleges based on the labor literacy classification framework was analyzed. The analysis found that: students occupy a core position in the evaluation, labor behavior and cognition are the cornerstone of the evaluation system, labor value is closely related to scientific and technological innovation and industrial synergy development. Labor attitude gradually moves from inside to outside to synergy, and there is some ambiguity in the evaluation of labor quality. Based on the findings, it is suggested to strengthen the scientific and technological innovation orientation of labor literacy, integrate the elements of industrial synergy development, flexibly respond to the industrial needs of different regions, diversify the participation of evaluation subjects, further improve the labor literacy evaluation mechanism, enhance students’ ability to adapt to technological and industrial changes, and cultivate more innovative skilled talents for high-quality development.