Based on the establishment of comprehensive evaluation systems, the level of digital economy and high quality development of manufacturing of provinces and cities from 2013 to 2021 in China are researched . Then the mechanism of the two are examined. The results show that the development of digital economy and manufacturing shows great differences among all regions. Digital economy significantly promotes the high quality development of manufacturing. Compared to digital industrialization, industrial digitization shows a more powerful and significant positive effect on the high quality development of manufacturing. The double threshold effects show that the level of industrialization should be in the right range or the influence digital economy on the development of manufacturing will be weakened or even turned into a negative one.