The digital economy drives the rational allocation and efficient utilization of various production factors in social production, promotes the balance between supply and demand, promotes the digital transformation of various industries, and accelerates industrial transformation, then it has become a booster for promoting high-quality economic development.The data from 2011 to 2021 was selected,the intermediary effect model was adopted,the effect of digital economy and human capital on industrial structure upgrade was examined.The results show that the digital economy has a significant role in promoting industrial structure upgrade, and the intermediary effect shows that human capital indirectly promotes industrial structure upgrade, and the effect of human capital in the digital economy to promote industrial structure upgrading cannot be ignored.