Aiming at the problem that there is no universal standard for the empirical value of shear wave velocity with depth in geotechnical investigation and seismic engineering in Tangshan area, the shear wave velocity data of 209 engineering geological boreholes in the planning area of Tangshan City as the research object was selected,the regression analysis method was adopted, and the regression analysis model under different geological zones and different lithology conditions was established. The fitting degree of the data was tested by the R2 value of the determination coefficient, and the optimal regression equation was proposed in the study area, and the regression equation was verified by the actual drilling data. The verification results show that compared with the two existing models in the research area, the regression equation established in this work is more accurate and has higher precision, which can become an important basis for the development and construction of the research area, and play a positive role in saving costs, shortening the construction period and improving work efficiency.