The Pearl River Delta region is one of the important demonstration regions in China's economic development from high-speed development stage to high-quality development stage. From "innovation, coordination, green, openness and sharing", an evaluation system of 25 specific indicators is constructed, and the entropy value method and geographic information system are used to measure the level and spatial characteristics of the high-quality economic development of the Pearl River Delta region from 2014 to 2019. The results show that the mean variation of the comprehensive score of high-quality economic development in the Pearl River Delta region is small and shows a small upward trend. Except for the openness dimension, which shows an obvious downward trend, the other four indicators have different fluctuations in growth. Shenzhen, Zhuhai and Guangzhou are the top performers in terms of high quality economic development，and coastal cities generally have higher overall scores， the overall spatial distribution shows an "M" pattern.