An evaluation index system of the effect of science and technology innovation policy implementation in Guangdong Province by referring to previous research results is constructed. By collecting statistical data from relevant yearbooks of Guangdong Province from 2014 to 2021，fuzzy comprehensive evaluation method and entropy method are used to calculate the scores of each index，and the effect of policy implementation is comprehensively evaluated and analyzed. The results show that the effect of science and technology innovation policy in Guangdong Province is getting well，but further improvement of science and technology innovation environment policy is needed. It is suggested to accelerate the formulation of innovation environment policies conducive to economic development，and strengthen the efficient implementation of science and technology innovation demand and supply policies.