The shortage of river sand has become a restricted problem in expressway construction, and the use of machine-made sand instead of river sand has become the development trend of infrastructure projects. Based on Chaohui Expressway, the technology research on the preparation of corrosion-resistant concrete with machine-made sand instead of river sand was carried out. In view of the lack of systematic technical guidance in the application of corrosion-resistant concrete with machine-made sand, the performance index system of corrosion-resistant concrete with machine-made sand was established. The key process of sand production and processing is analyzed, and the recommended equipment combination and parameter setting are put forward. The control standard of key performance indexes of manufactured sand products is put forward, and the recommended range is given for the mix design of concrete with different strength grades. The requirements and detection methods for the anti-corrosion performance of manufactured sand anti-corrosion concrete in different application scenarios of expressway are put forward. Based on the project, the solid test beam control test was carried out to compare the structural strength and anti-corrosion performance of the beam, and the engineering feasibility of the established performance index system of machine-made sand anti-corrosion concrete was verified.