In order to study the coordinated development status and influencing factors among the three systems of ecological environment, economic development and scientific and technological innovation in Henan Province, the comprehensive development level and coordinated development statusof these three systems were empirically analyzed in Henan Province from 2004 to 2020 by selecting multi-dimensional index data, entropy method and coupling coordination model. Then the comprehensive development level and coordinated development of the three systems were compared and analyzed between Henan Province and 30 provinces in China in 2020. It is found that the backwardness of ecological environment protection generally exists in all provinces in China. Compared with other provinces, the comprehensive development level of ecological environment in Henan Province is very backward. From 2004 to 2020, the increase of the coupling coordination degree of the three systems in Henan Province is mainly driven by the coordinated development between economic development and scientific and technological innovation. Finally, relevant suggestions are put forward.