Research the construction of rute network for cargo airlines. Improve the traditional model based on a single allocation strict hub route network. Replace the traditional unit transportation cost and discount factor with the commissioned transportation cost of goods on each route and the transportation cost of its own fleet, and consider the impact of the transit cost and loading rate of hub points on route selection. Considering the characteristics of air cargo night flights and the limitations of available time for each fleet at night, with the goal of minimizing total cost, a mathematical model is constructed and solved using LINGO optimization software to verify the effectiveness of the model, providing reference for freight airlines to build a freight route network.