Fully promoting the revitalization of northern Anhui is the key to seizing important development opportunities after Anhui Province joins the Yangtze River Delta Economic Zone. Therefore，based on the development status of the “four modernizations” in northern Anhui and the comprehensive development index system，the entropy weight method was used to analyze the comprehensive development trend and space-time difference characteristics of the “four modernizations synchronization”in northern Anhui in 2011-2021，and the GM (1,N) driving force model was constructed to explore the main driving factors affecting the comprehensive development of the “four modernizations synchronization”.The results show that the comprehensive development level of “four modernizations synchronization”in northern Anhui has significantly improved，the new industrialization and informatization have a stronger driving effect on the comprehensive development of“four modernizations synchronization”．However， there are significant spatiotemporal differences in the development level of “four modernizations”in different cities．Based on the analysis results，a new path for high-quality coordinated development of the“four modernizations synchronization”has been constructed.