Scientific and technological talents play an important role in promoting the development of regional economy, industry and education. As a bridgehead for connecting with ASEAN countries, Guangxi is in a period of historic development opportunities, but it is obviously restricted by the structure and total amount of scientific and technological talents. On the basis of systematically sorting out the present situation of Guangxi science and technology talent cluster, the characteristics and limiting factors of Guangxi science and technology talent cluster are analyzed. Facing the macro plan of "14th Five-Year Plan", feasible suggestions on accelerating the agglomeration of scientific and technological talents in Guangxi are put forward from the aspects of policy formulation, industrial environment, talent attracting methods and talent security, to provide countermeasures and support for the optimization of the agglomeration of scientific and technological talents in Guangxi.