Based on the example of landslide project K243 along the river road in the reservoir area of Lancang River Huangdeng Hydropower Station, the study was conducted on the formation mechanism, deformation and failure mode, and treatment measures of the freshman engineering landslide and the ancient landslide, and the stable condition and residual sliding force of the landslide under the combination of multiple working conditions. The GEO5 software was used to establish the landslide model and analyze the changes in the internal force and displacement of the anti-slip pile, as well as the variation in the landslide stability during different treatment construction processes. The results of the study show that the K243 landslide is effectively managed by using the double-row rigid frame anti-slide pile, anchored sheet pile wall, filling earth counter pressure, and water interception and drainage measures. The shearing force and bending moment of the back row pile of the freshman engineering landslide are greater than front row pile, and the displacement of pile top of the back row pile is greater than that of the front row pile, while the shearing force and displacement of the front row piles of the ancient landslide are greater than back row pile. The percentage increase in the stability coefficient of the freshman engineering landslide during different construction processes is approximately double that of the ancient landslide. The K243 landslide treatment has proved to be successful and can provide a reference for the analysis and treatment of road landslides in the reservoir area.