The transformation of scientific and technological achievements in universities is an important new engine of high-quality development in China, and the importance of performance evaluation of it is increasingly prominent. In the face of the uncertain information appearing in the evaluation process, a cloud model was introduced, a performance evaluation model for the transformation of scientific and technological achievements in universities based on game theory combination of empowerment and cloud model was proposed, and the IKLCM method was used to calculate the cloud similarity distance and derive the evaluation results. Through the example analysis of universities in five provinces and cities in southwest China, the results show that the model integrates the subjective and objective factors, the combination weights are scientific and reasonable, and the performance cloud model evaluation can get accurate and reliable evaluation results.