Selecting 16 indicators of cultural industry and tourism industry in the Yangtze River Economic Belt from 2012 to 2020, entropy method is used to standardize and empower statistical indicators. The coordinated development level of cultural tourism integration is measured, and coupling coordination model, Moran index, standard deviation ellipse model and other methods are used to explore the coordinated development level of cultural tourism integration in the Yangtze River Economic Belt and its spatio-temporal evolution characteristics. The following research conclusions are drawn: In terms of coordination level, the development level of the coupling and coordination degree of cultural industry and tourism industry in the Yangtze River Economic Belt from 2012 to 2020 has gradually increased, but the coordination level is not good.In terms of spatial pattern, the integration level of culture and tourism in the Yangtze River Economic Belt from 2012 to 2020 has obvious local agglomeration characteristics. In terms of center of gravity migration, the center of gravity of the coupling coordination degree of the integration of culture and tourism in the Yangtze River Economic Belt shifted to the southwest from 2012 to 2020.