According to the pressure-state-response (PSR) model, eco-sustainable development dilemma of manufacturing talents in Zhuzhou City is diagnosed systematically. The results show that there exists ecological niche deviation, including insufficient ecological niche breadth, lack of ecological niche validity, and symbiotic deterioration. The all-inclusive corrections for ecological niche of manufacturing talents in Zhuzhou city is a system engineering for maintaining eco-sustainable development of manufacturing talents,including guaranteeing city-manufacturing industry-talent integration, constructing open and inclusive vitality system for scientific and technological innovation of manufacturing talents, improving policy support for integrated services of manufacturing talents, building happy home for living ecological optimization of manufacturing talents, and forming long-term mechanism for diverse development of manufacturing talents.