Based on the data of 12 leagues and cities in Inner Mongolia Autonomous Region from 2013 to 2018, guided by high-quality economic development, based on the new development concept, combined with the regional characteristics of Inner Mongolia Autonomous Region, a comprehensive evaluation index system of high-quality economic development is constructed.The entropy weight TOPSIS evaluation model is used to measure and analyze the high-quality economic development level of 12 leagues and cities in Inner Mongolia Autonomous Region, and the obstacle degree model is used to find out the index dimensions that affect the development of each league city. Finally, the Moran index is used to measure and analyze the spatial correlation of high-quality economic development in Inner Mongolia Autonomous Region.The results show that the overall level of high-quality economic development in Inner Mongolia Autonomous Region is not very high, showing a pattern of "high in the middle and west, low in the east" development style, and gradually showing a significant correlation in spatial characteristics during the development process. In the future, it is necessary to take targeted measures in combination with the actual situation of each city to further promote high-quality economic development in Inner Mongolia Autonomous Region.