As the key link of high-rise building construction, the factors that affect pumping concrete quality are complex. The risk factors of pumping concrete pipe blocking accident are taken as the research object, and the DEMATEL-ISM model is constructed to clarify the key factors affecting the risk of pumping concrete pipe blocking accident and the hierarchical structure and action mechanism of each factor. The results show that the 22 influencing factors of pumping concrete plugging accident risk can be divided into four levels, in which the rationality of concrete mix ratio is the most core and fundamental factor affecting the risk of pumping concrete plugging accident, and has the greatest influence on other factors. Concrete construction fluidity, output pressure stability and pipeline smoothness have the most direct effect on the risk of pipe blocking accident.