The highway bridge crossing the landslide leads to highway safety operation problems and serious economic losses. The landslide of BK0+601 bridge of Yujiahai was adopted as an example. Field investigation and borehole analysis are the main means to analyze the development mechanism and disaster mode of landslide.A treatment plan is proposed for this landslide.The results show that increase of accumulation loading of landslides and cutting slope in the front edge of landslide reduced the stability of the slope, which leaded to the occurrence of disaster under the coupled of rainfall. Engineering facilities were damaged by pulling function of landslide caused by the toe cutting due to reservoir dredging. And disaster modes of landslide were revealed, including the damage of drainage channel, the tension crack of pier foundation, the damage of superstructure and the river-blocking event. The stability calculation were showed that the landslide was in an unstable state. Local sliding would occur under rainfall in the future.The suggestions of targeted treatment and bridge reinforcement treatment are put forward.