By constructing the evaluation index system for integrated development of culture and tourism , BP neural network and coupling coordination degree model are used to quantitatively analyze the cultural and tourism integration level of 10 cities in Huaihai Economic Zone. The results show that the cultural resources in Huaihai Economic Zone have a certain "agglomeration", and the abundance of cultural resources presents a "+" character distribution, and the development level of tourism industry in different cities is significantly different. The coupling synergy between the abundance of cultural resources and the development level of tourism industry is slightly maladjusted, and the internal differences are large, showing the spatial differentiation characteristics of southern Shandong > Northern Jiangsu > Northern Anhui > Eastern Henan. The integration process of culture and tourism is influenced by many factors.