From the perspective of proximity, the patent data jointly applied by industry, university and research of Jiangxi aviation manufacturing industry cluster from 2008 to 2019 is taken as an example.The negative binomial regression method is used to explores the impact of geographical, organizational and technological proximity and the interaction between each proximity on the collaborative innovation of the aviation manufacturing industry cluster. The results show that geographical proximity and organizational proximity promote the collaborative innovation of industrial clusters; Technology proximity has a negative impact on industrial cluster collaborative innovation.Geographical proximity positively regulates the relationship between organizational proximity and industrial cluster collaborative innovation, while geographical proximity negatively regulates the relationship between technological proximity and industrial cluster collaborative innovation.