Due to the complexity and variability of the actual environment, the strength parameters of the natural sedimentary soil of the slope are anisotropic and heterogeneous, and the change of the strength parameters has an impact on the safety factor of the slope. Based on the influence of anti-slide pile soil arching effect, considering the anisotropy and heterogeneity of soil strength parameters of slope, the anti-slide pile slope model with soil strength anisotropy and heterogeneity is established by programming the secondary development of finite element software, and the change of slope safety factors under the isotropic and anisotropic soil strength parameters are analyzed. The results show that when the heterogeneity coefficient of each anisotropy is 0.5, it has the greatest impact on the safety factor of the anti-slide pile slope, which is 22.9 % lower than that of the isotropic homogeneous slope. Compared with the horizontal cohesion strength, the vertical influence on the stability of anti-slide pile slope is greater, and the anisotropy and heterogeneity of soil are very important for the stability analysis of anti-slide pile slope.