Based on the panel data of 30 provinces, autonomous regions and municipalities in China from 2009 to 2020,spatial durbin model (SDM) using two weight matrices is constructed to empirically investigate the effect of government support on regional innovation quality. The results show that: Regional innovation quality has a significant positive spatial correlation. Influenced by the spatial factors of both geographical distance and economic distance, government support of a certain place can promote the innovation quality of this region and other regions. Moreover, the effect of economic distance is stronger. Financial development level of one province significantly improved the innovation quality of this province, and the opening level significantly improved the innovation quality in other regions.