In the context of the construction of the Guangdong-Hong Kong-Macao Greater Bay Area Traditional Chinese Medicine Highland, taking the active role of science and technology intermediaries in the transformation of scientific and technological achievements as the starting point, a tripartite evolutionary game model including the supply-side, demand-side and intermediary of the transformation of scientific and technological achievements of Chinese medicine is constructed, by analyzing the evolution and stability strategy of the model, and MATLAB is used to simulate the model. The results show that there are four possible combinations of evolutionary stability strategies for replicating dynamic systems, and betrayal revenue, transformation costs, and government support are the main factors affecting evolutionary stability strategies. The greater the profit of betrayal, the higher the conversion cost, and the smaller the government support, the game players tend to be non-cooperative and non-intervention. Finally,relevant suggestions to promote the transformation of scientific and technological achievements of Chinese medicine are put forward in the Guangdong-Hong Kong-Macao Greater Bay Area.