The drastic changes in the international flow of innovation factors and the acceleration of the revolution of science and technology industry, innovation driven, independent and controllable and other major national development strategies and industrial transformation and upgrading urgently need the strong support of local scientific and technological innovation to accelerate the transformation from scientific and technological innovation to industrial innovation. For a long time, the industrial demand and application mode of scientific and technological innovation have been regarded as ready conditions and have not been included in the industrialization process, which is in great contrast to practice. modes of promoting the industrialization of scientific and technological innovation are compared and analyzed, such as Stanford International Research Institute (SRI), Jiangsu Industrial Technology Research Institute (JITRI) and Enlisting and Leading, the mechanism of setting up an innovation "mixer" are discusses to carry out the forward-looking resource utilization of scientific and technological innovation, so as to cross the "valley of death" of innovation, and corresponding policy suggestions are put forward.