Retail industry plays a leading role in the connection between supply and demand, and retail digital innovation drives the reconstruction of the linkage mechanism between retail and manufacturing. In the process of promoting the quality and efficiency of manufacturing industry by retail digital at the present stage, there are constraints such as insufficient digital transformation of retail, insufficient management capacity of supply chain, difficult reorganization of manufacturing production process, and insufficient integration and creation of heterogeneous resources. From the perspective of retail concept construction, digital infrastructure construction, the improvement of retail digital supply chain capacity, the construction of C2M agile mode in manufacturing industry to the integration of heterogeneous resources in retail-manufacturing, the realization path of retail digital innovation to promote the improvement of quality and efficiency in manufacturing industry is proposed. By giving full play to the leading role of retail, the upgrading of manufacturing value chain is promoted, and the high-quality integrated development of related industries will realize.